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Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA

Abstract:

Influenza viruses have a segmented viral RNA (vRNA) genome, which is replicated by the viral RNA-dependent RNA polymerase (RNAP). Replication initiates on the vRNA 3' terminus, producing a complementary RNA (cRNA) intermediate, which serves as a template for the synthesis of new vRNA. RNAP structures show the 3' terminus of the vRNA template in a pre-initiation state, bound on the surface of the RNAP rather than in the active site; no information is available on 3' cRNA binding. Here, we have...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/nar/gkw884

Authors


Robb, Nicole C. More by this author
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Department:
Oxford, MSD, Pathology Dunn School
Wieneke, R. More by this author
Cordes, .T More by this author
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Funding agency for:
te Velthuis, Aartjan J. W.
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Funding agency for:
te Velthuis, Aartjan J. W.
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Publication date:
2016-09-30
Acceptance date:
2016-09-23
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:647882
URN:
uri:bec32d72-4423-47e0-8c28-42d4075ad31b
UUID:
uuid:bec32d72-4423-47e0-8c28-42d4075ad31b
Local pid:
pubs:647882

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