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Variant antigens and endothelial receptor adhesion in Plasmodium falciparum.

Abstract:

Parasite-derived proteins expressed on the surface of erythrocytes infected with Plasmodium falciparum are important virulence factors, since they mediate binding of infected cells to diverse receptors on vascular endothelium and are targets of a protective immune response. They are difficult to study because they undergo rapid clonal antigenic variation in vitro, which precludes the derivation of phenotypically homogeneous cultures. Here we have utilized sequence-specific proteases to dissec...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.93.8.3503

Authors


Gardner, JP More by this author
Pinches, RA More by this author
Roberts, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
93
Issue:
8
Pages:
3503-3508
Publication date:
1996-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:be77e016-5307-4890-ac53-76a08eba74e0
Source identifiers:
26403
Local pid:
pubs:26403

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