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Structure of Staphylococcus aureus guanylate monophosphate kinase.

Abstract:

Nucleotide monophosphate kinases (NMPKs) are potential antimicrobial drug targets owing to their role in supplying DNA and RNA precursors. The present work reports the crystal structure of Staphylococcus aureus guanylate monophosphate kinase (SaGMK) at 1.9 A resolution. The structure shows that unlike most GMKs SaGMK is dimeric, confirming the role of the extended C-terminus in dimer formation as first observed for Escherichia coli GMK (EcGMK). One of the two SaGMK dimers within the crystal a...

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Publication status:
Published

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Publisher copy:
10.1107/s174430910603613x

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Journal:
Acta crystallographica. Section F, Structural biology and crystallization communications
Volume:
62
Issue:
Pt 10
Pages:
949-953
Publication date:
2006-10-01
DOI:
EISSN:
1744-3091
ISSN:
1744-3091
Source identifiers:
72638

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