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Journal article

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study.

Abstract:

BACKGROUND: High-resolution magnetic resonance imaging (cine-MRI) is well suited for determining global cardiac function longitudinally in genetically or surgically manipulated mice, but in practice it is seldom used to its full potential. In this study, male and female guanidinoacetate N-methyltransferase (GAMT) knockout, and wild type littermate mice were subjected to a longitudinal cine-MRI study at four time points over the course of one year. GAMT is an essential enzyme in creatine biosy...

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Publication status:
Published

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Publisher copy:
10.1186/1532-429x-10-9

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Volume:
10
Issue:
1
Pages:
9
Publication date:
2008-01-01
DOI:
EISSN:
1532-429X
ISSN:
1097-6647
URN:
uuid:be6911c4-71dd-4350-a31f-5cb9c5a65ae7
Source identifiers:
34130
Local pid:
pubs:34130

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