Journal article
A single immunization with MVA expressing GnGc glycoproteins promotes epitope-specific CD8+-T cell activation and protects immune-competent mice against a lethal RVFV infection
- Abstract:
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BACKGROUND: Rift Valley fever virus (RVFV) is a mosquito-borne pathogen causing an important disease in ruminants often transmitted to humans after epizootic outbreaks in African and Arabian countries. To help combat the spread of the disease, prophylactic measures need to be developed and/or improved. METHODOLOGY/PRINCIPAL FINDINGS: In this work, we evaluated the immunogenicity and protective efficacy of recombinant plasmid DNA and modified vaccinia virus Ankara (rMVA) vectored vaccines aga...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pntd.0002309
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Neglected Tropical Diseases More from this journal
- Volume:
- 7
- Issue:
- 7
- Pages:
- e2309
- Publication date:
- 2013-07-11
- Acceptance date:
- 2013-05-30
- DOI:
- EISSN:
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1935-2735
- ISSN:
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1935-2727
Item Description
- Language:
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English
- Keywords:
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- UUID:
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uuid:be6753c0-b06b-46b2-b362-43953deee57d
- Local pid:
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pubs:417315
- Source identifiers:
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417315
- Deposit date:
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2013-11-17
Terms of use
- Copyright holder:
- López-Gil et al
- Copyright date:
- 2013
- Notes:
- © 2013 López-Gil et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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