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A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat.

Abstract:

BACKGROUND: The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microarrays to RNA-seq and investigate the ability of both platforms to detect differentially expressed genes following nerve injury using the L5 spinal nerve transection model of neuropathic pain. We also investigate the effects of increasing RNA-seq sequencing depth. Finally we t...

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Publication status:
Published

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Publisher copy:
10.1186/1744-8069-10-7

Authors


Perkins, JR More by this author
Antunes-Martins, A More by this author
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Publisher:
BioMed Central Ltd.
Journal:
Molecular pain
Volume:
10
Issue:
1
Pages:
7
Publication date:
2014
DOI:
EISSN:
1744-8069
ISSN:
1744-8069
URN:
uuid:be520cd6-7810-4e38-ac9e-ccfc9551a21b
Source identifiers:
464944
Local pid:
pubs:464944

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