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Serum protein profiling by miniaturized solid-phase extraction and matrix-assisted laser desorption/ionization mass spectrometry.

Abstract:

Serum profiling by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) holds promise as a clinical tool for early diagnosis of cancer and other human diseases. Sample preparation is key to achieving reproducible and well-resolved signals in MALDI-MS; a prerequisite for translation of MALDI-MS based diagnostic methods to clinical applications. We have investigated a number of MALDI matrices and several miniaturized solid-phase extraction (SPE) methods for serum protein con...

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Publication status:
Published

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Publisher copy:
10.1002/rcm.1960

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
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Journal:
Rapid communications in mass spectrometry : RCM
Volume:
19
Issue:
12
Pages:
1578-1586
Publication date:
2005-01-01
DOI:
EISSN:
1097-0231
ISSN:
0951-4198
URN:
uuid:be2c6325-cd67-44f7-987e-2eaecc3000e2
Source identifiers:
384615
Local pid:
pubs:384615

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