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Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.

Abstract:

Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are the two major causative agents of hand, foot and mouth disease (HFMD), for which there are currently no licenced treatments. Here, the acquisition of resistance towards two novel capsid-binding compounds, NLD and ALD, was studied and compared to the analogous compound GPP3. During serial passage, EV71 rapidly became resistant to each compound and mutations at residues I113 and V123 in VP1 were identified. A mutation at residue 113 was a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.antiviral.2015.10.006

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Structural Biology
Elliott, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Sanofi Pasteur More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Antiviral research Journal website
Volume:
124
Pages:
77-82
Publication date:
2015-12-05
DOI:
EISSN:
1872-9096
ISSN:
0166-3542
URN:
uuid:be28355e-3169-44a4-88be-18316e86f6d3
Source identifiers:
575130
Local pid:
pubs:575130

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