Genomic characterization of <i>bla</i> <sub>OXA-48</sub> -carrying IncL plasmids in <i>Enterobacterales</i> in Vietnam

Journal article

Carbapenem-hydrolyzing β-lactamase (carbapenemase) genes have been disseminated among bacteria worldwide; however, only a few instances of bacterial isolates harboring the carbapenemase gene bla OXA-48 have been reported in Vietnam. Here we report the first genetic characterization of bla OXA-48 -harboring Enterobacterales isolates in Vietnam. Three isolates- Enterobacter hormaechei , Klebsiella pneumoniae , and Escherichia coli -were clinically collected in Hanoi between 2010 and 2015. Whole-genome sequencing revealed that these isolates carried bla OXA-48 on nearly identical IncL plasmids, closely related to globally disseminated pOXA-48a-like plasmids. Our findings highlight the potential spread of highly transmissible bla OXA-48 -carrying plasmids in Vietnam, emphasizing the importance of continued surveillance.

Authors: Dieu Tran, L; Thai Pham, D; Duong Tran, N; Anh Dang, D; Anh Tran, H

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Caltech Library
• Journal: microPublication Biology
• Volume: 2025
• Publication date: 2025-10-14
• Acceptance date: 2025-10-10
• DOI: 10.17912/micropub.biology.001603
• EISSN: 2578-9430
• ISSN: 2578-9430
• Pmid: 41170436
• Language: English