- Abstract:
-
Roundabout (Robo) receptors provide an essential repulsive cue in neuronal development following Slit ligand binding. This important signaling pathway can also be hijacked in numerous cancers, making Slit-Robo an attractive therapeutic target. However, little is known about how Slit binding mediates Robo activation. Here we present the crystal structure of Robo1 Ig1-4 and Robo1 Ig5, together with a negative stain electron microscopy reconstruction of the Robo1 ectodomain. These results show h...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.0mb)
-
- Publisher copy:
- 10.1016/j.str.2017.12.003
-
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 26
- Issue:
- 2
- Pages:
- 320-328.e4
- Publication date:
- 2018-01-04
- Acceptance date:
- 2017-12-04
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Pubs id:
-
pubs:817795
- URN:
-
uri:be0a2013-3c10-49e3-bddd-4452c617dbcb
- UUID:
-
uuid:be0a2013-3c10-49e3-bddd-4452c617dbcb
- Local pid:
- pubs:817795
- Language:
- English
- Keywords:
- Copyright holder:
- European Molecular Biology Laboratory
- Copyright date:
- 2018
- Notes:
-
Copyright © 2017 European Molecular Biology Laboratory. Published by Elsevier Ltd.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Robo1 forms a compact dimer-of-dimers assembly
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