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Robo1 forms a compact dimer-of-dimers assembly

Abstract:

Roundabout (Robo) receptors provide an essential repulsive cue in neuronal development following Slit ligand binding. This important signaling pathway can also be hijacked in numerous cancers, making Slit-Robo an attractive therapeutic target. However, little is known about how Slit binding mediates Robo activation. Here we present the crystal structure of Robo1 Ig1-4 and Robo1 Ig5, together with a negative stain electron microscopy reconstruction of the Robo1 ectodomain. These results show h...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2017.12.003

Authors


Aleksandrova, N More by this author
Gutsche, I More by this author
Kandiah, E More by this author
Avilov, SV More by this author
Petoukhov, MV More by this author
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Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
26
Issue:
2
Pages:
320-328.e4
Publication date:
2018-01-04
Acceptance date:
2017-12-04
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pubs id:
pubs:817795
URN:
uri:be0a2013-3c10-49e3-bddd-4452c617dbcb
UUID:
uuid:be0a2013-3c10-49e3-bddd-4452c617dbcb
Local pid:
pubs:817795

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