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Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.

Abstract:

UNLABELLED: The negative-sense RNA genome of influenza A virus is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP). The viral RdRP is an important host range determinant, indicating that its function is affected by interactions with cellular factors. However, the identities and the roles of most of these factors remain unknown. Here, we employed affinity purification followed by mass spectrometry to identify cellular proteins that interact with the influenza A virus...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01813-14

Authors


Hutchinson, EC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of virology
Volume:
88
Issue:
22
Pages:
13284-13299
Publication date:
2014-11-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:be00da4b-44f2-408c-a5cb-746cf085d549
Source identifiers:
483522
Local pid:
pubs:483522
Language:
English

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