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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.

Abstract:

In eukaryotic cells degradation of bulk mRNA in the 5' to 3' direction requires the consecutive action of the decapping complex (consisting of DCP1 and DCP2) and the 5' to 3' exonuclease XRN1. These enzymes are found in discrete cytoplasmic foci known as P-bodies or GW-bodies (because of the accumulation of the GW182 antigen). Proteins acting in other post-transcriptional processes have also been localized to P-bodies. These include SMG5, SMG7, and UPF1, which function in nonsense-mediated mR...

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Publisher copy:
10.1261/rna.2191905

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
Journal:
RNA (New York, N.Y.)
Volume:
11
Issue:
11
Pages:
1640-1647
Publication date:
2005-11-05
DOI:
EISSN:
1469-9001
ISSN:
1355-8382
URN:
uuid:bdedfc05-ec3e-4e57-9647-73f388362b96
Source identifiers:
353657
Local pid:
pubs:353657

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