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Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion.

Abstract:

The junctional adhesion molecules (JAMs) have been recently described as interendothelial junctional molecules and as integrin ligands. Here we show that JAM-B and JAM-C undergo heterophilic interaction in cell-cell contacts and that JAM-C is recruited and stabilized in junctional complexes by JAM-B. In addition, soluble JAM-B dissociates soluble JAM-C homodimers to form JAM-B/JAM-C heterodimers. This suggests that the affinity of JAM-C monomers to form dimers is higher for JAM-B than for JAM...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e05-04-0310

Authors


Lamagna, C More by this author
Mandicourt, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
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Journal:
Molecular biology of the cell
Volume:
16
Issue:
10
Pages:
4992-5003
Publication date:
2005-10-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:bdebe4c3-874f-43bf-92ef-927a2388d1e5
Source identifiers:
17468
Local pid:
pubs:17468

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