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Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

Abstract:

IL1-beta production by mononuclear cells isolated from normal and active inflammatory bowel disease mucosa was studied. Significantly more IL1-beta was produced spontaneously by mononuclear cells from the inflamed mucosa compared with those from normal colonic mucosa (median 190 pg/ml (range 45-700) v 20 pg/ml (0-165)). Stimulation with lipopolysaccharide enhanced IL1-beta production by mononuclear cells from active inflammatory bowel disease mucosa but not those from normal mucosa. Depleting...

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Publication status:
Published

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Publisher copy:
10.1136/gut.30.6.835

Authors


Journal:
Gut
Volume:
30
Issue:
6
Pages:
835-838
Publication date:
1989-06-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:bdce84a1-dd6b-47db-be7a-6c46ea6b645b
Source identifiers:
135362
Local pid:
pubs:135362

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