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Anti-Inflammatory Microglia/Macrophages as a Potential Therapeutic Target in Brain Metastasis

Abstract:

Brain metastasis is a common complication of cancer patients and is associated with poor survival. Histological data from patients with brain metastases suggest that microglia are the major immune population activated around the metastatic foci. Microglia and macrophages have the ability to polarise to different phenotypes and to exert both tumorigenic and cytotoxic effects. However, the role of microglia/macrophages during the early stages of metastatic growth in the brain has not yet been d...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.3389/fonc.2017.00251

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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More from this funder
Funding agency for:
Andreou, KA
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Oncology Journal website
Publication date:
2017-01-01
Acceptance date:
2017-10-09
DOI:
EISSN:
2234-943X
Pubs id:
pubs:735189
URN:
uri:bd5cd8cc-f41e-400e-aed4-ada69f734f52
UUID:
uuid:bd5cd8cc-f41e-400e-aed4-ada69f734f52
Local pid:
pubs:735189

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