Journal article
Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos.
- Abstract:
- In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.3MB, Terms of use)
-
- Publisher copy:
- 10.1038/s41598-017-06459-7
Authors
+ Biotechnology and Biological Sciences Research Council
More from this funder
- Grant:
- Doctoral Training Fellowship
- Publisher:
- Nature Publishing Group
- Journal:
- Scientific Reports More from this journal
- Volume:
- 7
- Issue:
- 1
- Pages:
- 6475
- Publication date:
- 2017-07-01
- Acceptance date:
- 2017-06-13
- DOI:
- ISSN:
-
2045-2322
- Pmid:
-
28743923
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:709595
- UUID:
-
uuid:bd2f8bca-4e0e-41a7-8c41-e9a6877a05d1
- Local pid:
-
pubs:709595
- Source identifiers:
-
709595
- Deposit date:
-
2018-03-13
Terms of use
- Copyright holder:
- Wilson and Coverley
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record