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Peptides for nucleic acid delivery

Abstract:

Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells. To overcome this, many different drug delivery systems have been devised. Among others, short delivery peptides, called cell-penetrating peptides (CPPs), have been demonstrated t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.addr.2016.06.008

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Funding agency for:
El Andaloussi, S
Publisher:
Elsevier Publisher's website
Journal:
Advanced Drug Delivery Reviews Journal website
Volume:
106
Issue:
Pt A
Pages:
172-182
Publication date:
2016-06-24
Acceptance date:
2016-06-15
DOI:
EISSN:
1872-8294
ISSN:
0169-409X
Pubs id:
pubs:631399
URN:
uri:bd10897f-ed45-4769-bb4b-8255aa17b532
UUID:
uuid:bd10897f-ed45-4769-bb4b-8255aa17b532
Local pid:
pubs:631399

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