Journal article
Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection
- Abstract:
- Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 81.7KB, Terms of use)
-
- Publisher copy:
- 10.1097/qad.0000000000002165
Authors
- Publisher:
- Lippincott, Williams & Wilkins
- Journal:
- AIDS More from this journal
- Volume:
- 33
- Issue:
- 7
- Pages:
- 1253-1256
- Publication date:
- 2019-06-01
- Acceptance date:
- 2019-01-15
- DOI:
- EISSN:
-
1473-5571
- ISSN:
-
0269-9370
- Pmid:
-
31045943
- Language:
-
English
- Pubs id:
-
1004153
- Local pid:
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pubs:1004153
- Deposit date:
-
2020-06-02
- ARK identifier:
Terms of use
- Copyright holder:
- Wolters Kluwer Health
- Copyright date:
- 2019
- Rights statement:
- Copyright © 2019 Wolters Kluwer Health, Inc.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Lippincott, Williams & Wilkins at https://dx.doi.org/10.1097/qad.0000000000002165
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