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A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.

Abstract:

Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as "rosettes." Despite a well documented association between rosetting and severe malaria, it is controversial whether rosetting is a cause or a correlate of parasite virulence. CR1-deficient RBC show greatly reduced rosetting; therefore, we hypothesized that, if rosetting is a direct cause of malaria pathology, CR1-deficie...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0305306101

Authors


Cockburn, IA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
O'Donnell, A More by this author
Moulds, JM More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
1
Pages:
272-277
Publication date:
2004-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:bcef2042-0a03-4648-af3a-6de700c8e054
Source identifiers:
90485
Local pid:
pubs:90485

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