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Leprosy and the adaptation of human toll-like receptor 1.

Abstract:

Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world. Despite several major studies on susceptibility to leprosy, few genomic loci have been replicated independently. We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susce...

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Authors


Gochhait, S More by this author
Malhotra, D More by this author
Pettersson, FH More by this author
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Journal:
PLoS pathogens
Volume:
6
Publication date:
2010
EISSN:
1553-7374
URN:
uuid:bce2454b-ab4c-4727-8bfe-b6711f469a32
Source identifiers:
245990
Local pid:
pubs:245990

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