Thesis
Identification of new therapeutic targets and drug repositioning in myelodysplastic syndromes using transcriptional profiling and connectivity mapping
- Abstract:
-
The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal haematopoietic stem cell (HSC) malignancies that are characterised by ineffective haematopoiesis leading to peripheral blood cytopenias at one or more lineages. There are few effective treatments for this disorder, and the identification of new therapeutic agents in MDS is urgently needed. Drug repurposing is a potential alternative to novel drug discovery by redirecting existing drugs for treating another disease, whi...
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Authors
Contributors
+ Pellagatti, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- RDM
- Role:
- Supervisor
- ORCID:
- 0000-0002-6122-0221
+ Boultwood, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- RDM
- Role:
- Supervisor
- ORCID:
- 0000-0002-4330-2928
+ Pezzella, F
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- RDM
- Role:
- Examiner
+ Verma, A
- Institution:
- Albert Einstein College of Medicine
- Role:
- Examiner
+ China Scholarship Council
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100004543
- Funding agency for:
- Sun, T
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2021-07-19
Terms of use
- Copyright holder:
- Sun, T
- Copyright date:
- 2021
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