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IFITM3 Rs12252-C Variant Increases Potential Risk for Severe Influenza Virus Infection in Chinese Population.

Abstract:

Background: Interferon Inducible Transmembrane 3 (IFITM3) is a key factor in interferon pathway and it involves host's immune response against multiple viruses. IFITM3 rs12252-C was associated with severe influenza virus infection in several studies, however whether this association is universal to all types of influenza virus or diverse ethnic populations remain controversial.

Method: A case-control genetic association study was performed from September 2013 to Apri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fcimb.2017.00294

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cellular and Infection Microbiology Journal website
Volume:
7
Pages:
294
Publication date:
2017-06-30
Acceptance date:
2017-06-16
DOI:
EISSN:
2235-2988
Pubs id:
pubs:709564
URN:
uri:bc97a542-a90e-4518-a084-7b83bde5fbe9
UUID:
uuid:bc97a542-a90e-4518-a084-7b83bde5fbe9
Local pid:
pubs:709564

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