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BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development.

Abstract:

Beclin 1/Atg6 is an essential component of the evolutionary conserved PtdIns(3)-kinase (Vps34) protein complex that regulates macroautophagy (autophagy) in eukaryotic cells and also interacts with antiapoptotic Bcl-2 family members, Bcl-2, and Bcl-x(L). To elucidate the physiological function of Beclin 1, we generated transgenic mice producing a green fluorescent Beclin 1 protein (Beclin 1-GFP) under Beclin 1 endogenous regulation. The beclin 1-GFP transgene is functional because it completel...

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Publication status:
Published

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Publisher copy:
10.1038/cdd.2008.59

Authors


Matthews, G More by this author
Coradin, J More by this author
Hartmann, B More by this author
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Journal:
Cell death and differentiation
Volume:
15
Issue:
9
Pages:
1385-1395
Publication date:
2008-09-05
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
URN:
uuid:bc8f9fe6-2516-4f45-a270-b06224513412
Source identifiers:
23599
Local pid:
pubs:23599

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