Genome-wide meta-analysis of short-tandem repeats for Parkinson’s disease risk using genotype imputation

Journal article

Idiopathic Parkinson’s disease is determined by a combination of genetic and environmental factors. Recently, the first genome-wide association study on short-tandem repeats in Parkinson’s disease reported on eight suggestive short-tandem repeat-based risk loci (α = 5.3 × 10−6), of which four were novel, i.e. they had not been implicated in Parkinson’s disease risk by genome-wide association analyses of single-nucleotide polymorphisms before. Here, we tested these eight candidate short-tandem...

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Authors: Ohlei, O; Paul, K; Nielsen, SS; Gmelin, D; Dobricic, V

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Brain Communications
• Volume: 6
• Issue: 3
• Article number: fcae146
• Publication date: 2024-04-23
• Acceptance date: 2024-02-26
• DOI: 10.1093/braincomms/fcae146
• EISSN: 2632-1297
• Language: English
• Keywords: genome-wide association study; short-tandem repeats; Parkinson’s disease; microsatellites; DNA methylation