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Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial

Abstract:

Background: WHO recommends gametocytocidal, single low-dose primaquine for blocking the transmission of Plasmodium falciparum; however, safety concerns have hampered the implementation of this strategy in sub-Saharan Africa. We aimed to investigate the safety of age-dosed, single low-dose primaquine in children from Uganda and the Democratic Republic of the Congo.

Methods: We conducted this randomised, double-blind, placebo-c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/s1473-3099(22)00658-2

Authors


Publisher:
Elsevier
Journal:
Lancet Infectious Diseases More from this journal
Volume:
23
Issue:
4
Pages:
471-483
Publication date:
2022-11-30
Acceptance date:
2022-09-28
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Pmid:
36462528
Language:
English
Keywords:
Pubs id:
1311338
Local pid:
pubs:1311338
Deposit date:
2023-01-27

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