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Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel.

Abstract:

A homology model has been generated for the pore-forming domain of Kir6.2, a component of an ATP-sensitive K channel, based on the x-ray structure of the bacterial channel KcsA. Analysis of the lipid-exposed and pore-lining surfaces of the model reveals them to be compatible with the known features of membrane proteins and Kir channels, respectively. The Kir6.2 homology model was used as the starting point for nanosecond-duration molecular dynamics simulations in a solvated phospholipid bilay...

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Publication status:
Published

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Authors


Capener, CE More by this author
Shrivastava, IH More by this author
Ranatunga, KM More by this author
Forrest, LR More by this author
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Journal:
Biophysical journal
Volume:
78
Issue:
6
Pages:
2929-2942
Publication date:
2000-06-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:bc0a36c6-5457-47f1-81bf-4adeb142ebf6
Source identifiers:
100652
Local pid:
pubs:100652

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