Journal article
Fosfomycin as a potential treatment for neonatal sepsis An open label randomised clinical trial evaluating safety and pharmacokinetics
- Abstract:
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Objective To assess pharmacokinetics and changes to sodium levels in addition to adverse events (AEs) associated with fosfomycin among neonates with clinical sepsis. Design A single-centre open-label randomised controlled trial. Setting Kilifi County Hospital, Kenya. Patients 120 neonates aged ≤28 days admitted being treated with standard-of-care (SOC) antibiotics for sepsis: ampicillin and gentamicin between March 2018 and February 2019. Intervention We randomly assigned half the partici...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 5.5MB, Terms of use)
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- Publisher copy:
- 10.1136/archdischild-2021-322483
Authors
Funding
Bibliographic Details
- Publisher:
- BMJ Publishing Group
- Journal:
- Archives of Disease in Childhood More from this journal
- Volume:
- 107
- Issue:
- 9
- Pages:
- 802-810
- Publication date:
- 2022-01-25
- Acceptance date:
- 2021-12-24
- DOI:
- EISSN:
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1474-4457
- ISSN:
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1473-3099
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1110955
- Local pid:
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pubs:1110955
- Deposit date:
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2020-06-09
Terms of use
- Copyright holder:
- Obiero et al.
- Copyright date:
- 2022
- Rights statement:
- © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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