A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study.

Journal article

CONTEXT: Subclinical hypothyroidism (SCH) and cognitive dysfunction are both common in the elderly and have been linked. It is important to determine whether T4 replacement therapy in SCH confers cognitive benefit. OBJECTIVE: Our objective was to determine whether administration of T4 replacement to achieve biochemical euthyroidism in subjects with SCH improves cognitive function. DESIGN AND SETTING: We conducted a double-blind placebo-controlled randomized controlled trial in the context of...

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Authors: Parle, J; Roberts, L; Wilson, S; Pattison, H; Roalfe, A

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 95
• Issue: 8
• Pages: 3623-3632
• Publication date: 2010-08-01
• DOI: 10.1210/jc.2009-2571
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Thyrotropin; Intention to Treat Analysis; Treatment Outcome; Double-Blind Method; Neuropsychological Tests; Immunoassay; Hypothyroidism; Aged; Thyroid Function Tests; Humans; Great Britain; Aged, 80 and over; Female; Thyroxine; Male; Cognition; Cognition Disorders; Thyroid Gland; Cross-Sectional Studies