Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast.

Journal article

The aim of this study was to assess the expression of IGF-I and IGF-II in phyllodes tumours and fibroadenomas and to see if there is any correlation between nuclear beta-catenin expression and IGF-I and IGF-II expression in these tumours. In a previous study, it has been shown that Wnt signalling is important in the pathogenesis of phyllodes tumours of the breast. Epithelial Wnt5a overexpression and stromal Wnt2 overexpression were associated with abnormal, nuclear localization of beta-cateni...

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Authors: Sawyer, E; Hanby, A; Poulsom, R; Jeffery, R; Gillett, C

• Journal: Journal of pathology
• Volume: 200
• Issue: 5
• Pages: 627-632
• Publication date: 2003-08-01
• DOI: 10.1002/path.1391
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: Insulin-Like Growth Factor II; Neoplasm Proteins; Insulin-Like Growth Factor I; Humans; Cytoskeletal Proteins; Breast Neoplasms; Phyllodes Tumor; Somatomedins; Trans-Activators; Immunoenzyme Techniques; Cell Nucleus; Fibroadenoma; beta Catenin; Female