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The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease.

Abstract:

Dopamine neurons of the substantia nigra pars compacta (SNc) are uniquely sensitive to degeneration in Parkinson's disease (PD) and its models. Although a variety of molecular characteristics have been proposed to underlie this sensitivity, one possible contributory factor is their massive, unmyelinated axonal arbor that is orders of magnitude larger than other neuronal types. We suggest that this puts them under such a high energy demand that any stressor that perturbs energy production lead...

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Publication status:
Published online

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Publisher copy:
10.3389/fncom.2013.00013

Authors


Pissadaki, EK More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Frontiers in computational neuroscience
Volume:
7
Pages:
13
Publication date:
2013-01-05
DOI:
EISSN:
1662-5188
ISSN:
1662-5188
URN:
uuid:bbd1e9dd-f607-4f9e-9d46-37823d526ae3
Source identifiers:
391069
Local pid:
pubs:391069

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