- Abstract:
-
Dopamine neurons of the substantia nigra pars compacta (SNc) are uniquely sensitive to degeneration in Parkinson's disease (PD) and its models. Although a variety of molecular characteristics have been proposed to underlie this sensitivity, one possible contributory factor is their massive, unmyelinated axonal arbor that is orders of magnitude larger than other neuronal types. We suggest that this puts them under such a high energy demand that any stressor that perturbs energy production lead...
Expand abstract - Publication status:
- Published online
- Publisher copy:
- 10.3389/fncom.2013.00013
-
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- Journal:
- Frontiers in computational neuroscience
- Volume:
- 7
- Pages:
- 13
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1662-5188
- ISSN:
-
1662-5188
- URN:
-
uuid:bbd1e9dd-f607-4f9e-9d46-37823d526ae3
- Source identifiers:
-
391069
- Local pid:
- pubs:391069
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease.
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