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Galectin-3 binds Neisseria meningitidis and increases interaction with phagocytic cells

Abstract:

Galectin-3 is expressed and secreted by immune cells and has been implicated in multiple aspects of the inflammatory response. It is a glycan binding protein which can exert its functions within cells or exogenously by binding cell surface ligands, acting as a molecular bridge or activating signalling pathways. In addition, this lectin has been shown to bind to microorganisms. In this study we investigated the interaction between galectin-3 and Neisseria meningitidis, an important extracellul...

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Journal:
Cellular Microbiology
Volume:
14
Issue:
11
Pages:
1657-1675
Publication date:
2012-11-05
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
URN:
uuid:bbb7d39a-c458-4bb2-9907-705dd564a904
Source identifiers:
359765
Local pid:
pubs:359765
Language:
English

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