Journal article
Data-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis
- Abstract:
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While unbiased proteomics of human cerebrospinal fluid (CSF) has been used successfully to identify biomarkers of amyotrophic lateral sclerosis (ALS), high-abundance proteins mask the presence of lower abundance proteins that may have diagnostic and prognostic value. However, developments in mass spectrometry (MS) proteomic data acquisition methods offer improved protein depth. In this study, MS with library-free data-independent acquisition (DIA) was used to compare the CSF proteome of pe...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.6MB, Terms of use)
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- Publisher copy:
- 10.1111/jnc.16030
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Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Journal of Neurochemistry More from this journal
- Volume:
- 168
- Issue:
- 2
- Pages:
- 115-127
- Publication date:
- 2023-12-12
- Acceptance date:
- 2023-12-02
- DOI:
- EISSN:
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1471-4159
- ISSN:
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0022-3042
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1582321
- Local pid:
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pubs:1582321
- Deposit date:
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2023-12-19
Terms of use
- Copyright holder:
- Dellar et al.
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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