Journal article
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- Abstract:
- © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to. Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findings from Mendelian randomisation studies depend on specific assumptions. We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to interpret findings from Mendelian randomisation studies in the context of other sources of evidence.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 645.3KB, Terms of use)
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- Publisher copy:
- 10.1136/bmj.k601
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- BMJ More from this journal
- Volume:
- 362
- Issue:
- 2018
- Article number:
- k601
- Publication date:
- 2018-07-12
- Acceptance date:
- 2017-12-04
- DOI:
- EISSN:
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1756-1833
- ISSN:
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0959-8138
- Pmid:
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30002074
- Language:
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English
- Pubs id:
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pubs:891429
- UUID:
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uuid:bb904131-d1b2-4572-a4e3-a0a2e177e753
- Local pid:
-
pubs:891429
- Source identifiers:
-
891429
- Deposit date:
-
2019-02-27
Terms of use
- Copyright holder:
- Davies et al
- Copyright date:
- 2018
- Notes:
- This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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