Rostral migratory stream neuroblasts turn and change directions in stereotypic patterns.

Journal article

Neuroblasts generated in the adult subventricular zone (SVZ) migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB). Previous work uncovered motility ranging from straight to complex, but it was unclear if directional changes were stochastic or exhibited stereotypical patterns. Here, we provide the first in-depth two-photon time-lapse microscopy study of morphological and dynamic features that accompany turning and direction reversals in the RMS. We identified three spe...

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Authors: Martinez-Molina, N; Kim, Y; Hockberger, P; Szele, F

• Publication status: Published
• Journal: Cell adhesion and migration
• Volume: 5
• Issue: 1
• Pages: 83-95
• Publication date: 2011-01-01
• DOI: 10.4161/cam.5.1.13788
• EISSN: 1933-6926
• ISSN: 1933-6918
• Language: English
• Keywords: Male; Cerebral Ventricles; Olfactory Bulb; Neurogenesis; Mice, Transgenic; Mice, Inbred C57BL; Cell Movement; Signal Transduction; Mice; Neurons; Female; Neural Stem Cells; Brain; Animals