A multidisciplinary approach to giant cell tumors of tendon sheath and synovium--a critical appraisal of literature and treatment proposal.

Journal article

Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular.

Authors: van der Heijden, L; Gibbons, C; Hassan, A; Kroep, JR; Gelderblom, H

• Publication status: Published
• Journal: Journal of surgical oncology
• Volume: 107
• Issue: 4
• Pages: 433-445
• Publication date: 2013-03-01
• DOI: 10.1002/jso.23220
• EISSN: 1096-9098
• ISSN: 0022-4790
• Language: English
• Keywords: Tendons; Radiotherapy, Adjuvant; Neoplasm Recurrence, Local; Tenosynovitis; Magnetic Resonance Imaging; Interdisciplinary Communication; Female; Pyrimidines; Adult; Middle Aged; Antineoplastic Agents; Male; Radioisotopes; Piperazines; Protein-Tyrosine Kinases; Pyrroles; Indoles; Giant Cell Tumors; Protein Kinase Inhibitors; Chemotherapy, Adjuvant; Molecular Targeted Therapy; Synovial Membrane; Arthroplasty; Arthroscopy; Humans