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CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

Abstract:

Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by controlling the phosphorylation status of S281 in the kinetochore-binding domain. This regulation is essential for checkpoint signaling, since MPS1S281A is not recruited to unattached kinetochores and fails to support the recruitment of other ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1083/jcb.201808014

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0002-6717-2232
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
218
Issue:
4
Pages:
1182
Publication date:
2019-01-23
Acceptance date:
2019-01-07
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pubs id:
pubs:966129
URN:
uri:bb4cb495-1407-4f3c-8a31-d4f086ef895d
UUID:
uuid:bb4cb495-1407-4f3c-8a31-d4f086ef895d
Local pid:
pubs:966129
Language:
English
Keywords:

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