- Abstract:
-
Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by controlling the phosphorylation status of S281 in the kinetochore-binding domain. This regulation is essential for checkpoint signaling, since MPS1S281A is not recruited to unattached kinetochores and fails to support the recruitment of other ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 3.0MB)
-
- Publisher copy:
- 10.1083/jcb.201808014
-
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- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Cell Biology Journal website
- Volume:
- 218
- Issue:
- 4
- Pages:
- 1182
- Publication date:
- 2019-01-23
- Acceptance date:
- 2019-01-07
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- Pubs id:
-
pubs:966129
- URN:
-
uri:bb4cb495-1407-4f3c-8a31-d4f086ef895d
- UUID:
-
uuid:bb4cb495-1407-4f3c-8a31-d4f086ef895d
- Local pid:
- pubs:966129
- Language:
- English
- Keywords:
- Copyright holder:
- Hayward et al.
- Copyright date:
- 2019
- Notes:
- © 2019 Hayward et al. https://creativecommons.org/licenses/by/4.0/ This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
Journal article
CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization
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