The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.

Journal article

The development of gene delivery systems for therapeutic use involves vectors (often retrovirus or adenovirus) which typically encode one target protein, but the use of internal ribosome entry sites (IRES) can confer the ability to express more than one protein from bi- or polycistronic mRNAs. IRES elements can display tissue-specific expression, so it is necessary to determine suitable IRES for specific clinical applicability. Blood vessel endothelial cells are important clinically since man...

Expand abstract

Authors: Chung, G; Yamada, Y; Pannell, R; Forster, A; Rabbitts, T

• Journal: Nucleic acids research
• Volume: 31
• Issue: 8
• Pages: e46
• Publication date: 2003-04-01
• DOI: 10.1093/nar/gng046
• EISSN: 1362-4962
• ISSN: 0305-1048
• Language: English
• Keywords: Neoplasm Transplantation; Protein Biosynthesis; Mice; Hepacivirus; LIM Domain Proteins; Endothelium, Vascular; Animals; Female; Mice, Inbred C57BL; Male; Metalloproteins; Adaptor Proteins, Signal Transducing; Neovascularization, Pathologic; Embryo, Mammalian; Plasmids; Binding Sites; Ribosomes; Neoplasms, Experimental; Lac Operon; DNA-Binding Proteins; Tumor Cells, Cultured