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Journal article

Reduced C-afferent fibre density affects perceived pleasantness and empathy for touch.

Abstract:

We examined patients with a heritable disorder associated with a mutation affecting the nerve growth factor beta gene. Their condition has been classified as hereditary sensory and autonomic neuropathy type V. Carriers of the mutation show a reduction in density of thin and unmyelinated nerve fibres, including C afferents. A distinct type of unmyelinated, low-threshold mechanoreceptive C fibre, the C-tactile afferent, is present in hairy but not glabrous skin of humans and other mammals. They...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awr011

Authors


Morrison, I More by this author
Löken, LS More by this author
Wessberg, J More by this author
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Journal:
Brain : a journal of neurology
Volume:
134
Issue:
Pt 4
Pages:
1116-1126
Publication date:
2011-04-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:bb36b997-cee8-4118-bfeb-f69a5202f4af
Source identifiers:
243881
Local pid:
pubs:243881

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