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Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity, and impaired glucose tolerance

Abstract:

The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine 1H-NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n = 50) and show that microbial-host co-metabolites are prodromal (i.e., early) markers predicting future divergence in metabolic (obesity and glucose homeostasis) and behavioral (anxiety and activity) outcomes with 9...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.06.039

Authors


Dumas, M-E More by this author
Rothwell, AR More by this author
Aranias, T More by this author
Chilloux, J More by this author
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European Commission More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
1
Pages:
136-148
Publication date:
2017-07-05
Acceptance date:
2017-06-12
DOI:
ISSN:
2211-1247
Pubs id:
pubs:707912
URN:
uri:bb30e12a-8ecc-4451-9fa6-5cfb552927b3
UUID:
uuid:bb30e12a-8ecc-4451-9fa6-5cfb552927b3
Local pid:
pubs:707912

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