The tumour necrosis factor receptor family: life or death choices.

Journal article

The past twelve months have seen a renewal of interest in the therapeutic potential of members of the tumour necrosis factor receptor family and their cytokine ligands. This biomedical interest has spawned a number of structural studies, which have significantly deepened our understanding of the molecular basis for the function of these cell-surface signalling systems. The fresh data have revealed unexpected mechanisms conferring ligand-receptor specificity and have highlighted the structural...

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Authors: Jones, E

• Publication status: Published
• Journal: Current opinion in structural biology
• Volume: 10
• Issue: 6
• Pages: 644-648
• Publication date: 2000-12-01
• DOI: 10.1016/s0959-440x(00)00149-4
• EISSN: 1879-033X
• ISSN: 0959-440X
• Language: English
• Keywords: Models, Molecular; Signal Transduction; Protein Conformation; Ligands; Receptors, Tumor Necrosis Factor