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A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis.

Abstract:

Deposits of Ig and complement are abundant in affected joints of patients with rheumatoid arthritis (RA) and in animal models of RA in which antibodies are demonstrably pathogenic. To identify molecular targets of the Igs deposited in arthritic joints, which may activate local inflammation, we used a combination of mass spectrometry (MS) and protein microarrays. Immune complexes were affinity-purified from surgically removed joint tissues of 26 RA and osteoarthritis (OA) patients. Proteins co...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0908032106

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
37
Pages:
15867-15872
Publication date:
2009-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:bb16bdc4-f1c8-4f19-a60b-cf4b31054968
Source identifiers:
1852
Local pid:
pubs:1852

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