Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs.

Journal article

The introduction of 5-HT3 antagonists, such as ondansetron, as antiemetic agents has transformed the management of patients receiving chemotherapy or radiation therapy. Studies in animal models with NK1 antagonists suggest that these represent a new class of antiemetic agents having a broader spectrum of activity than 5-HT3 antagonists. Compounds of this class may prove to be more effective in man against delayed emesis induced by cisplatin, post-operative nausea and vomiting and motion sickness. Thus, they have the potential to complement 5-HT3 antagonists and so provide a further advance in the management of nausea and vomiting.

Authors: Bountra, C; Gale, J; Gardner, C; Jordan, C; Kilpatrick, G

• Publication status: Published
• Journal: Oncology
• Volume: 53 Suppl 1
• Issue: SUPPL. 1
• Pages: 102-109
• Publication date: 1996-06-01
• DOI: 10.1159/000227649
• EISSN: 1423-0232
• ISSN: 0030-2414
• Language: English
• Keywords: Reflex; Antiemetics; Vomiting; Animals; Forecasting; Receptors, Neurokinin-1; Humans