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Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.

Abstract:

Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda after a standard fixed oral artemether-lumefantrine treatment. Dense venous (n = 26) and sparse capillary (n = 90) lumefantrine samples were drawn from pregnant patients. A total of 17 nonpregnant women contributed with dense venous ...

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Publisher copy:
10.1038/psp.2013.59

Authors


Kloprogge, F More by this author
Muwanga, S More by this author
Turyakira, E More by this author
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Journal:
CPT: pharmacometrics and systems pharmacology
Volume:
2
Issue:
11
Pages:
e83
Publication date:
2013
DOI:
EISSN:
2163-8306
URN:
uuid:bae9c035-f799-41f2-a1fc-0013105cc304
Source identifiers:
438852
Local pid:
pubs:438852
Language:
English

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