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A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

Abstract:

Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.3058

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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089276/Wellcome Trust More from this funder
/Wellcome Trust More from this funder
1S10OD018111/NIH HHS More from this funder
AI094386/NIAID NIH HHS More from this funder
G0400720/Medical Research Council More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Immunology Journal website
Volume:
16
Issue:
2
Pages:
170–177
Publication date:
2014-12-15
Acceptance date:
2014-11-18
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:499670
URN:
uri:bab75f6a-8b3c-42e8-9bee-638edc381e63
UUID:
uuid:bab75f6a-8b3c-42e8-9bee-638edc381e63
Local pid:
pubs:499670
Language:
English
Keywords:

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