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Epistasis can lead to fragmented neutral spaces and contingency in evolution.

Abstract:

In evolution, the effects of a single deleterious mutation can sometimes be compensated for by a second mutation which recovers the original phenotype. Such epistatic interactions have implications for the structure of genome space--namely, that networks of genomes encoding the same phenotype may not be connected by single mutational moves. We use the folding of RNA sequences into secondary structures as a model genotype-phenotype map and explore the neutral spaces corresponding to networks o...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.2011.2183

Authors


Schaper, S More by this author
Johnston, IG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
279
Issue:
1734
Pages:
1777-1783
Publication date:
2012-05-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:baaf30a0-8271-404a-b2d0-cfd0bf9c334e
Source identifiers:
264209
Local pid:
pubs:264209

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