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Cardiac myosin binding protein C: its role in physiology and disease.

Abstract:

Myosin binding protein-C (MyBP-C) is a thick filament-associated protein localized to the crossbridge-containing C zones of striated muscle sarcomeres. The cardiac isoform is composed of eight immunoglobulin I-like domains and three fibronectin 3-like domains and is known to be a physiological substrate of cAMP-dependent protein kinase. MyBP-C contributes to thick filament structure via interactions at its C-terminus with the light meromyosin section of the myosin rod and with titin. The prot...

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Publication status:
Published

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Authors


Flashman, E More by this author
Redwood, C More by this author
Moolman-Smook, J More by this author
Watkins, H More by this author
Journal:
Circulation research
Volume:
94
Issue:
10
Pages:
1279-1289
Publication date:
2004-05-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:ba8baa19-c53e-49ef-ac62-fe89973cf9c5
Source identifiers:
104215
Local pid:
pubs:104215

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