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Proximal promoter elements of the human zeta-globin gene confer embryonic-specific expression on a linked reporter gene in transgenic mice.

Abstract:

We have investigated the transcriptional regulation of the human embryonic zeta-globin gene promoter. First, we examined the effect that deletion of sequences 5' to zeta-globin's CCAAT box have on zeta-promoter activity in erythroid cell lines. Deletions of sequences between -116 and -556 (cap = 0) had little effect while further deletion to -84 reduced zeta-promoter activity by only 2-3-fold in both transiently and stably transfected erythroid cells. Constructs containing 67, 84 and 556 bp o...

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Publication status:
Published

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Publisher copy:
10.1093/nar/24.21.4158

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Journal:
Nucleic acids research
Volume:
24
Issue:
21
Pages:
4158-4164
Publication date:
1996-11-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:ba83d2cf-5d5d-497b-a7a2-7e5a7af7a529
Source identifiers:
27855
Local pid:
pubs:27855

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