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Journal article : Review

Regional specialization of macrophages along the gastrointestinal tract

Abstract:
The tissue microenvironment is a major driver in imprinting tissue-specific macrophage functions in various mammalian tissues. As monocytes are recruited into the gastrointestinal (GI) tract at steady state and inflammation, they rapidly adopt a tissue-specific and distinct transcriptome. However, the GI tract varies significantly along its length, yet most studies of intestinal macrophages do not directly compare the phenotype and function of these macrophages in the small and large intestine, thus leading to disparities in data interpretations. This review highlights differences along the GI tract that are likely to influence macrophage function, with a specific focus on diet and microbiota. This analysis may fuel further investigation regarding the interplay between the intestinal immune system and GI tissue microenvironments, ideally providing unique therapeutic targets to modulate specific intestinal macrophage populations and/or functions.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.it.2021.07.006

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0002-9045-6348

Publisher:
Cell Press
Journal:
Trends in Immunology More from this journal
Volume:
42
Issue:
9
Pages:
795-806
Publication date:
2021-08-06
Acceptance date:
2021-07-15
DOI:
EISSN:
1471-4981
ISSN:
0167-5699

Language:
English
Keywords:
Subtype:
Review
Pubs id:
1187248
Local pid:
pubs:1187248
Deposit date:
2021-07-21
ARK identifier:

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