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Exploiting real-time genomic surveillance data to assess 4CMenB meningococcal vaccine performance in Scotland, 2015 to 2022

Abstract:

The United Kingdom implemented the first national infant immunization schedule for the meningococcal vaccine 4CMenB (Bexsero) in September 2015, targeting serogroup B invasive meningococcal disease (IMD). Bexsero contains four variable subcapsular proteins, and postimplementation IMD surveillance was necessary, as nonhomologous protein variants can evade Bexsero-elicited protection. We investigated postimplementation IMD cases reported in Scotland from 1 September 2015 to 30 June 2022. Pat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/mbio.00499-23

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Biology
Role:
Author
Publisher:
American Society for Microbiology
Journal:
mBio More from this journal
Volume:
14
Issue:
2
Publication date:
2023-04-10
Acceptance date:
2023-03-06
DOI:
EISSN:
2150-7511
ISSN:
2161-2129
Language:
English
Keywords:
Pubs id:
1331546
Local pid:
pubs:1331546
Deposit date:
2023-03-07

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