Journal article
Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells.
- Abstract:
-
Signaling via the type 1 insulin-like growth factor receptor (IGF1R) confers resistance to EGF receptor (EGFR) inhibitors. It is plausible that reciprocal EGFR compensation could mediate resistance to IGF1R inhibition, prompting us to investigate effects of IGF1R depletion on EGFR signaling in breast cancer cells expressing relatively high (MDA-MB-468) or low (MCF7) EGFR. Transient IGF1R knockdown induced enhanced phosphorylation of the EGFR and its effectors JNK, ERKs and STAT5, but this did...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bbrc.2007.02.041
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Bibliographic Details
- Journal:
- Biochemical and biophysical research communications
- Volume:
- 355
- Issue:
- 3
- Pages:
- 700-706
- Publication date:
- 2007-04-01
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- Source identifiers:
-
178489
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:178489
- UUID:
-
uuid:ba3ffb26-cc8e-4254-b71b-9028479f0835
- Local pid:
- pubs:178489
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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