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Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells.

Abstract:

Signaling via the type 1 insulin-like growth factor receptor (IGF1R) confers resistance to EGF receptor (EGFR) inhibitors. It is plausible that reciprocal EGFR compensation could mediate resistance to IGF1R inhibition, prompting us to investigate effects of IGF1R depletion on EGFR signaling in breast cancer cells expressing relatively high (MDA-MB-468) or low (MCF7) EGFR. Transient IGF1R knockdown induced enhanced phosphorylation of the EGFR and its effectors JNK, ERKs and STAT5, but this did...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbrc.2007.02.041

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Journal:
Biochemical and biophysical research communications
Volume:
355
Issue:
3
Pages:
700-706
Publication date:
2007-04-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:ba3ffb26-cc8e-4254-b71b-9028479f0835
Source identifiers:
178489
Local pid:
pubs:178489

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