- Abstract:
-
Signaling via the type 1 insulin-like growth factor receptor (IGF1R) confers resistance to EGF receptor (EGFR) inhibitors. It is plausible that reciprocal EGFR compensation could mediate resistance to IGF1R inhibition, prompting us to investigate effects of IGF1R depletion on EGFR signaling in breast cancer cells expressing relatively high (MDA-MB-468) or low (MCF7) EGFR. Transient IGF1R knockdown induced enhanced phosphorylation of the EGFR and its effectors JNK, ERKs and STAT5, but this did...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bbrc.2007.02.041
-
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 355
- Issue:
- 3
- Pages:
- 700-706
- Publication date:
- 2007-04-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:ba3ffb26-cc8e-4254-b71b-9028479f0835
- Source identifiers:
-
178489
- Local pid:
- pubs:178489
- Copyright date:
- 2007
Journal article
Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells.
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